Slider v1.0 - Statistical Likelihood model for Identifying Differential Expression in R

Slider is a R package for identifying differential expression on Two dimensional polyacrylamide gel electrophoresis (2D PAGE). A limitation of 2D PAGE is the inability to detect a protein when its concentration falls below the limit of detection. Consequently, differential expression of proteins may be missed when the level of a protein in the cases or controls is below the limit of detection for 2D PAGE. Slider pakcage takes into account both detected and non-detected proteins. Non-detected proteins are classified either as (a) proteins that are not expressed in at least one replicate, or (b) are expressed but are below the limit of detection. Differentially expressed proteins can be detected by using a Likelihood Ratio Test (LRT)

OS Support

Slider is written using the R programming language.